Iovieno N, Papakostas GI, Feeney A, et al. - Researchers sought to perform a meta-analysis of studies of vortioxetine in adults with major depressive disorder (MDD). Using PubMed, they included 7,269 individual randomized to vortioxetine (n = 3,630) vs placebo (n = 3,639) from 17 studies. Findings suggest greater effectiveness of vortioxetine vs placebo in improving depression, anxiety, and cognition. The true treatment effect could not be assessed because of less informative or uninformative studies.