Kawai D, Takenaka R, Ishiguro M, et al. - Researchers conducted this prospective, single-center, randomized, open-label controlled trial (RCT) to assess the efficacy of vonoprazan in artificial ulcer healing following endoscopic submucosal dissection (ESD). In total, 168 patients with gastric tumors were analyzed and randomly assigned to the vonoprazan group (group V) or lansoprazole group (group L) after ESD. In patients who are not taking antithrombotic agents, NSAIDs, or steroids, vonoprazan may not be superior to lansoprazole in the healing of artificial gastric ulcers after ESD. However, the data are significant because the effect of vonoprazan is still debatable, and larger-scale RCTs are needed to validate the current findings.