Chotchutipan T, et al. - In patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and a ≤10 pack-year smoking history treated with chemoradiation, researchers sought to gauge the prognostic value of volumetric positron emission tomography (PET) parameters. They calculated the maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor, involved regional lymph nodes, and total lesion. In low-risk HPV-related OPSCC, volumetric PET parameters are uniquely prognostic of locoregional failure-free survival (LRFFS) and may be useful for directing de-intensification strategies.