Barbarawi M, Kheiri B, Zayed Y, et al. - Researchers analyzed literature data from PubMed, the Cochrane Library, and Embase, to determine whether vitamin D supplementation has any link with cardiovascular disease (CVD) risk. They identified randomized clinical trials that assessed the influence of long-term (≥ 1 year) vitamin D supplementation on CVD events and all-cause mortality, excluding those studies that did not include cardiovascular outcomes. The primary outcome was major adverse cardiovascular events and the secondary endpoints were rates of myocardial infarction, stroke or cerebrovascular accident, CVD mortality, and all-cause mortality. This study included 21 randomized clinical trials with 83,291 patients. Vitamin D and placebos were received by 41,669 and 41,622 patients respectively. The sample analyzed had a mean (SD) age 65.8 (8.4) years and 61,943 (74.4%) were female. Findings revealed no link of vitamin D supplementation with reduced major adverse cardiovascular events, individual CVD endpoints (myocardial infarction, stroke, CVD mortality), or all-cause mortality. Overall, no cardiovascular protective impact of vitamin D supplementation was found and it is not indicated for this purpose.