Zittermann A, et al. - Researchers undertook this investigation to determine the impact of a daily vitamin D₃ dose of 4000 IU on bone turnover markers (BTMs) in patients with advanced heart failure (HF) and 25-hydroxyvitamin D (25OHD) concentrations < 75 nmol/L. No effect of a daily vitamin D₃ dose of 4000 IU on BTMs was reported in this study. The observations pointed out that vitamin D supplementation will not lower bone turnover in male patients with heart failure.