Konstantinidis I, et al. - This trial ascertained if the deficiency of vitamin D₃ (VD3) correlated with the presence of nasal polyposis (NP) in patients with cystic fibrosis (CF) and patients with chronic rhinosinusitis (CRS). VD3 deficiency appeared to be related to the presence of nasal polyps in the patients with CRS and in the patients with CF in a similar manner. It was inferred that the lower the level of serum VD3, the more severe the mucosal disease was disclosed in the imaging studies and the more frequent microbial colonization of the patients with CF and the patients with CRS.

Methods

• During this study, 152 adults were included in five phenotypic groups: CF with NP (CFwNP) (n = 27), CF without NP (CFsNP) (n = 31), CRS with NP (CRSwNP) (n = 32), CRS without NP (CRSsNP) (n = 30), and controls (n = 32).
• Herein, the serum levels of 25(OH)-VD3 < 20 ng/mL were regarded as a deficiency, 21-29 ng/mL as insufficiency, and >30 ng/mL as sufficiency.
• Endoscopic and imaging staging of the mucosal disease were carried out with the Lund-Kennedy (LK) and Lund-Mackay (LM) scoring systems, respectively.
• This was followed by recording of the genotype of patients with CF and the nasal microbial colonization of the patients with CF and patients with CRS.

Results

• Among all the groups, lowest percentage of sufficiency in VD3 and the highest percentage in insufficiency was reported in the patients with CFwNP.
• The LM imaging scores exhibited an inverse connection with the VD3 levels in both arms of the study (CF and CRS).
• Similar link was observed by the LK endoscopic scores had in the CF groups. This was not true with the CRS groups.
• The genotype of the patients with CF did not associate with the VD3 serum levels. Substantially lower VD3 serum levels in both the CF and CRS process was discolsed among the patients with positive microbial colonization (mainly Pseudomonas and Staphylococcus aureus).