Makoui MH, et al. - Whether the risk of asthma is related to vitamin D receptor (VDR) gene polymorphisms (FokI (rs2228570) or / and TaqI (rs731236) or / and BsmI (rs1544410) or / and ApaI (rs7975232)), was investigated via this meta-analysis of 17 studies that were identified through systematically conducted electronic search of web of science, Scopus, and PubMed databases from inception until Jun 2019. FokI SNP (single nucleotide polymorphisms) and TaqI SNP had a statistical significant link with asthma risk, as revealed by the findings of the pooled analysis. Asthma risk in Asian, African and American populations was influenced by ethnicity, as revealed in subgroup analysis. The stability of the findings was corroborated in the sensitivity analyses. Findings revealed a link between VDR gene polymorphism and the risk of asthma.