Stefanidis C, et al. - Via literature review, researchers intended to clarify the links between circulating 25-hydroxyvitamin D (25(OH)D) level and secondary prevention of acute wheeze attacks in preschool and school-age children. Increased risk and frequency of future acute wheeze was reported in preschool age children with a history of wheeze attacks and circulating 25(OH)D <75 nmol/L. However, analysis of school-age children revealed no consistent link between low vitamin D status and risk of acute wheeze. Experts concluded that results of further trials are required to make an evidence-based recommendation for the use of vitamin D for preventing wheeze attacks. In order to avoid acute respiratory tract infections, and to preserve skeletal and general health in preschool and school-age children with acute wheeze, the value of evaluating circulating 25(OH)D level as well as of optimizing vitamin D status is suggested but it remained unclear if this would attenuate the risk of acute wheeze attacks.