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Vitamin D deficiency is associated with risk of developing peripheral arterial disease in type 2 diabetic patients

BMC Cardiovascular Disorders Jun 21, 2019

Yuan J, et al. - In this cross-sectional study with type 2 diabetes mellitus (T2DM) patients (n=1,018), researchers evaluated the link between serum 25-hydroxyvitamin D (25(OH)D) levels and peripheral arterial disease (PAD) prevalence. They measured serum 25(OH)D levels and recorded risk factors of PAD. Presence of an ankle-brachial index < 0.9 confirmed the diagnosis of PAD. Participants had a mean age of 58.59 ± 11.34 years. An increased risk of PAD was observed in relation to lower serum vitamin D levels in T2DM patients. The odds ratios of PAD were 3.587 and 5.540 in patients with a level of 10 to < 20 ng/mL and < 10 ng/mL, respectively, compared to those with serum 25(OH)D levels ≥20 ng/mL, after adjustment for age, sex, body mass index, smoking status and season.

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