Liu W, Zhou C, Wang Y, et al. - Serum 25 hydroxyvitamin D [25(OH)D] levels differ significantly between mild cognitive impairment (MCI) patients and cognitive healthy controls, and findings demonstrated the presence of a correlation between serum levels of 25(OH)D, lipids, and oxysterols and cognitive impairment among people.

• About 209 MCI patients and 209 healthy controls from China were included and their serum levels of 25(OH)D, lipids, and oxysterols were recorded.

• MCI was 3 times more likely to occur in participants with vitamin D deficiency than those with adequate vitamin D levels.

• AUC of 25(OH)D was 0.72 and the cut-off was 16.5 ng/mL (sensitivity: 50.3%, specificity: 84.4%).

• A negative correlation of serum 25(OH)D levels with total cholesterol, LDL-cholesterol, and 24S,25-epoxycholesterol was identified.

• Montreal Cognitive Assessment and symbol digit modalities test scores showed positive correlations with serum 25(OH)D levels.