Robbie H, et al. - In this investigation involving 273 subjects (212 men and 61 women; median age, 67 years) with a multidisciplinary diagnosis of idiopathic pulmonary fibrosis (IPF), researchers explored the connection between CT markers of lung volume and pulmonary function test (PFT) parameters of lung volume in IPF. On the basis of the intraclass correlation coefficient, the interobserver agreement for CT markers was assessed. A strong correlation existed between CT-derived automated lung volume and total lung capacity [TLC]. For all manual CT measurements, excellent interobserver agreement existed. Findings revealed that lung height had the greatest impact on the lung volume fit. The authors concluded that automated and manual lung volume CT measurements were significantly associated with lung volume parameters derived from PFT, regardless of fibrosis and emphysema.