Li TC, et al. – Researchers undertook this study to evaluate visit–to–visit variations in fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) represented by the coefficient of variation (CV) and to determine whether they were independently associated with Alzheimer disease (AD), irrespective of HbA1c and other traditional risk factors in such patients. It was noted that fasting plasma glucose coefficient of variation and HbA1c CV are independently correlated with AD. The correlations between glycemic variability and AD demonstrated in this study suggest a linked pathophysiological mechanism, which is worthy of further evaluation. Future study is needed to confirm the outcomes and to assess whether FPG CV and HbA1c CV can be valuable therapeutic targets for patients with T2DM at risk.