Visit-to-visit glycemic variability and risks of cardiovascular events and all-cause mortality: The ALLHAT Study
Diabetes Care Jan 24, 2019
Echouffo-Tcheugui JB, et al. - In this prospective cohort analysis, researchers assessed the impact of visit-to-visit variability (VVV) of fasting blood glucose (FBG) on incident cardiovascular disease (CVD) and mortality. The study sample consisted of 4,982 participants in the ALLHAT study who attended the baseline, 24-month, and 48-month visits. The highest quartile of SD of FBG or variability independent of the mean (VIM) conferred a higher risk of death among people without diabetes. Findings revealed that greater VVV of FBG—defined as the SD or VIM across FBG measurements obtained at the three visits—was correlated with increased mortality risk. Overall, findings emphasized the importance of achieving normal and consistent glycemic levels in order to improve clinical results.
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