Viscoelastometric-guided early fibrinogen concentrate replacement during postpartum haemorrhage: OBS2, a double-blind randomized controlled trial
British Journal of Anesthesia Sep 13, 2017
Collins PW, et al. - This study hypothesized that early fibrinogen replacement, guided by viscoelastometric testing, attenuates blood product usage and bleed size in postpartum haemorrhage (PPH). No improvement was evident in outcomes subsequent to infusion of fibrinogen concentrate triggered by Fibtem A5 ≤15 mm. As indicated in pre-specified subgroup analyses, if the Fibtem A5 is >12 mm or Clauss fibrinogen >2 g litre-1, there is no need for fibrinogen replacement, but an impact below these levels could not be excluded. In addition, the raised fibrinogen at term seemed to be a physiological buffer rather than required for haemostasis.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty
-
Paid Market Research Surveys
-
Case discussions, News & Journals' summaries