Lampe L, et al. - Authors evaluated 1825 subjects in the LIFE-adult study (age 20-82 years) using high-resolution 3-Tesla MRI to resolve the role of obesity in regional white matter hyperintensities (WMH). They estimated waist-to-hip ratio (WHR), body mass index (BMI), systolic/diastolic blood pressure, hypertension, diabetes and smoking status, blood glucose and inflammatory markers as well as the distribution of WMH. They observed WHR linked to raised WMH possibility predominantly in the deep white matter in obese people with high visceral fat accumulation but with an increase in pro-inflammatory cytokines, not dependent on common obesity co-morbidities like hypertension.