Duan X, Chen Z, Li X, et al. - As isolation is the most effective way to limit the spreading of the highly contagious hand, foot and mouth disease (HFMD), researchers sought to determine the duration of virus shedding of the HFMD-related enterovirus and a reasonable quarantine period for HFMD patients. In this systematic review and meta-analysis, the viral shedding was evaluated in patients with HFMD caused by Enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) and coxsackievirus A6. Inclusion of a total of 17 observational studies evaluating 626 participants was done. Per findings, the patients released from quarantine still exhibit high positive rates of virus shedding, and HFMD patients caused by different serotypes have inconsistent duration of viral shedding. In this study, comprehensive evidence was gained for a possible flexible quarantine period according to the serotype.