Malagón T, Louvanto K, Ramanakumar AV, et al. - In The Biomarkers of Cervical Cancer Risk study, a case-control study from 2001 to 2010 in Montréal, Canada of histologically-verified cervical intraepithelial neoplasia (CIN), adenocarcinoma in situ (AIS), or cervical cancer cases and controls of women showing up for routine screening with normal cytology outcomes, researchers evaluated whether human papillomavirus (HPV) viral load was an independent predictor of underlying cervical disease and its diagnostic efficiency by age. In normal, CIN1, CIN2, CIN3&AIS, and cervical cancer geometric mean HPV16/18/31/33/45 viral load rose with the severity of lesion grade, varying from 0.7, 3.1, 4.8, 7.2, and 12.4 copies/cell, respectively. This relationship was principally directed by HPV16, 18, and 31 viral loads. Therefore, it was discovered that in comparison with the accuracy that has been reported for other HPV screening triage tests, HPV viral load has lower diagnostic exactitude. Nonetheless, in settings without cytology outcomes like HPV self-sampling, for triaging HPV tests, it could be beneficial.