Nicola Napoli N, et al. - Researchers carried out a MrOS study which indicated that type 2 diabetes (T2DM) was not correlated with higher prevalent or incident vertebral-fracture in older men, even after adjustment for BMI and bone mineral density (BMD). The data showed that higher spine areal bone mineral density (aBMD) and volumetric bone mineral density (vBMD) are associated with lower prevalence and incidence of vertebral fracture in type 2 diabetes (T2DM) as well as non-diabetic men.

Methods

• They aimed to evaluate the impact of diabetes status on prevalent and incident vertebral fracture, and to estimate the impact of lumbar spine BMD (areal and volumetric) as a risk factor for prevalent and incident morphometric vertebral fracture in T2DM (n=875) and non-diabetic men (n=4679).
• They applied data from the Osteoporotic Fractures in Men (MrOS) Study, which enrolled men aged ≥65 years.
• They assessed lumbar spine areal BMD (aBMD) with dual x-ray absorptiometry (DXA), and volumetric BMD (vBMD) by quantitative computed tomography (QCT).

Results

• The data showed that frequency (7.0% vs.7.7%) and incidence (4.4% vs.4.5%) of vertebral fracture were not higher in T2DM vs. non-diabetic men.
• They noted that the risk of prevalent (OR 1.05, 95% CI 0.78-1.40) or incident vertebral-fracture (OR 1.28 95%CI 0.81-2.00) was not higher in T2DM versus non-diabetic men in models adjusted for age, clinic site, race, BMI and aBMD.
• The outcomes demonstrated that higher spine aBMD was correlated with lower risk of prevalent vertebral-fracture in T2DM (OR 0.55, 95% CI 0.48-0.63) and non-diabetic men (OR 0.66, 95% CI 0.5-0.88), (p for interaction=0.24) and of incident vertebral-fracture in T2DM (OR 0.50, 95% CI 0.41-0.60) and non-diabetic men (OR 0.54, 95% CI 0.33-0.88), (p for interaction=0.77).
• Outcomes were similar for vBMD.