Isidro RA, Dong F, Hornick JL, et al. - This study was intended to define the genomic landscape of esophageal verrucous carcinoma (VSCC) in comparison to conventional esophageal squamous cell carcinoma (SCC). Researchers distinguished three cases of VSCC from the Brigham and Women’s Hospital pathology archive. The findings revealed that VSCC is not only morphologically but also genetically distinct from conventional esophageal SCC, featuring frequent SMARCA4 mutations and infrequent TP53 mutations or CDKN2A/B copy number variants. It has been considered that molecular findings may aid in establishing the challenging diagnosis of VSCC.