Hulleman M, Salcido DD, Menegazzi JJ, et al. - For OHCA characteristics in out-of-hospital cardiac arrest (OHCA), ventricular fibrillation (VF) waveform analyses are considered a reliable proxy. Researchers here investigated how cardiovascular medication use influence amplitude spectrum area (AMSA) of VF, while correcting for the presence of cardiovascular disease (CVD), CVD risk factors, and OHCA characteristics. An OHCA registry in the Netherlands yielded data from 990 VF patients for whom information was available on medical history and cardiovascular medication use. When corrected for CVD, CVD risk factors and OHCA characteristics, the multivariate analysis revealed association of only potassium-sparing agents with a lower AMSA when compared with patients using other cardiovascular medications. As per observations, cardiovascular medication use is unlikely to produce strong and clinically relevant independent pharmacologic effect on AMSA. In OHCA, there seemed a possible utility of AMSA as patient management tool without considering cardiovascular medication use.