Shaikh S, et al. - Via systematically reviewing the literature, researchers sought to inscribe the existing VTE chemoprophylaxis regimens for obese trauma and surgical patients with their efficacy and safety as measured by the incidence of VTE, anti-factor Xa levels, and the occurrence of bleeding events. Searching seven literature databases including PubMed, Excerpta Medica Database, GoogleScholar, JAMA Network, CINAHL, Cochrane, and SAGE Journals, they identified 5,083 citations; of these, 45 studies with 27,717 patients met inclusion criteria. In this group, six studies examined weight-based dosing regimens, four employed a weight-stratified or weight-tiered approach, five employed a BMI–stratified strategy, 29 evaluated fixed-dose regimens, and two utilized continuous infusions. The analysis revealed more frequent achievement of target anti-Xa concentrations when using weight-based and high fixed-dose chemoprophylaxis regimens vs standard fixed-dose regimens but these were not associated with a reduction in VTE. Additionally, increased bleeding complications were observed in correlation with high fixed-dose approaches.