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Vedolizumab in patients with concurrent primary sclerosing cholangitis and inflammatory bowel disease does not improve liver biochemistry but is safe and effective for the bowel disease

Alimentary Pharmacology and Therapeutics Feb 01, 2018

Christensen B, et al. - This study was performed to describe the effect of the α4β7 integrin antibody, vedolizumab, on liver biochemistry and disease activity in patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). Liver biochemistry did not improve with vedolizumab treatment in patients with PSC and IBD. However, this treatment was correlated with improvement in bowel disease and a favourable safety profile.
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