Kim JW, et al. - In this investigation, researchers studied the associations between cerebral amyloid beta (Aβ) deposition and neurodegeneration (ND) with subjective memory complaints (SMCs) in cognitively normal (CN) people, with particular emphasis on the modulating effects of vascular risk (VR) on these relationships. In total, 230 CN elderly people had comprehensive clinical evaluations including the Subjective Memory Complaints Questionnaire (SMCQ), VR assessment, and multimodal brain imaging including [¹¹C] Pittsburgh compound B positron emission tomography (PET), [¹⁸F] fluorodeoxyglucose-PET, and magnetic resonance imaging. A significant overall positive association was found between cerebral Aβ retention and SMCQ score. They also found a significant cerebral Aβ retention × VR interaction effect on the SMCQ score. According to findings, early accumulation of Aβ in the brain reflects SMC in CN elderly people. Because of the modulating effect of VR on the relationship between Aβ and SMC, SMC can be used in individuals without VR as a meaningful marker of early Aβ deposition.