Rabin JS, et al. - Investigators studied if a well-validated measure of systemic vascular risk and β-amyloid (Aβ) burden is associated with regional tau burden using newly available positron emission tomography (PET) imaging. Baseline vascular risk was measured in 152 clinically normal older adults with the office-based Framingham Heart Study cardiovascular disease risk algorithm (FHS-CVD). Between FHS-CVD and Aβ burden there was a significant interaction on subsequently measured inferior temporal cortex (ITC) tau; combined higher FHS-CVD and elevated Aβ burden was related to increased tau. The interaction for entorhinal cortex (EC) tau was not significant. When coupled with high Aβ burden, the elevated vascular risk might influence tau burden. In this analysis, a potential link between vascular risk and tau pathology in preclinical Alzheimer's disease (AD) was suggested.