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Vascular inflammation in moderate‐to‐severe atopic dermatitis is associated with enhanced Th2 response

Allergy Apr 22, 2021

Villani AP, Pavel AB, Wu J, et al. - Researchers conducted the study for determining factors associated with vascular inflammation/atherosclerosis in atopic dermatitis (AD) patients. They used 18‐FDG PET‐CT to characterize vascular inflammation in AD patients and healthy individuals. Vascular inflammation in AD is linked to enhanced Th2 response and clinical severity, which may explain cardiovascular comorbidities seen in select AD populations. Larger prospective studies are required to further assess vascular inflammation and cardiovascular events and mortality in AD patients. Finally, as dupilumab therapy showed significant modulation of atherosclerosis‐related genes in AD patients vs placebo, these findings indicate that modulation of vascular inflammation with systemic treatment should be investigated in patients with AD.

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