Wang D, Shen Z, Fang X, et al. - Twelve tali were perfused with the contrast agent and then scanned with micro-computed tomography (microCT) by the researchers in order to investigate an optimal drilling depth and direction for osteochondral lesions of the talus based on a 3-dimensional vascular microarchitecture model constructed with microCT. The vessel density of the 0 to 5 mm depth was lower vs the 5 to 10 mm and 10 to 15 mm depths, however, no important variation between the 5 to 10 mm and 10 to 15 mm depth was detected. The vessel density in the 5 to 10 mm depth of the medial talar dome was comparable to that of the adjacent zones. Vessel density in the 5 to 10 mm depth around the lateral talar dome was greater in the anterior and medial side. The anterolateral approach disrupted the main intraosseous vessels from the tarsal canal–tarsal sinus, causing an extensive vascular compromise in the talus neck and body, whereas the posterolateral approach interrupted only the vessels near the tunnel. In conclusion, the vessel density changed greatly from the subchondral 0 to 5 mm to the 5 to 10 mm depth. The vessel densities of the 5 to 10 mm depth around the medial talar dome were comparable, whereas the anterior and medial side of the lateral talar dome was better vascularized. The posterolateral approach led to less vascular damage in comparison with the anterolateral approach.