Ma Y, Wolters FJ, Chibnik LB, et al. - Researchers investigated the association of blood pressure variation over a period of years, considering both magnitude and direction, with the risk of dementia. They performed a prospective cohort study including 5,273 dementia-free participants (58.1% women; mean age, 67.6 [8.0] years). Dementia occurred in 1,059 cases during a median follow-up of 14.6 years. An increased risk of dementia was noted in correlation to large blood pressure variation, measured over two sequential visits every 4 years apart, especially when this variation occurred long before the diagnosis. A higher long-term risk was evident in correlation to both large rises and falls in blood pressure.