Palacios-Ceña M, et al. - Researchers studied 173 individuals with tension-type headache (TTH) to determine how clinical, psychological, and psychophysical outcomes differ with respect to the use of prophylactic medication (amitriptyline) in TTH. Forty-nine (28%) patients reported prophylactic medication use for headaches (amitriptyline: 100%). Patients with higher headache frequency, higher headache burden, worse sleep quality, and higher depression tended to use prophylactic medication. They observed widespread pain hyperalgesia in correlation with lower effectiveness of prophylactic amitriptyline.