Zhou R, Liu HM, Li FR, et al. - In this population-based cohort study, researchers intended to determine if there is a correlation of visit-to-visit variability in BMI, mean arterial pressure, total cholesterol, triglycerides, HbA1c, high-sensitivity C-reactive protein, ferritin, and fibrinogen with cognitive decline. The sample consisted of 2,260 people (mean age = 63.0 [SD = 7.5] years) free of cognitive diseases who underwent ≥ 3 clinical measurements from 2004 to 2019. Higher BMI, mean arterial pressure, total cholesterol, HbA1c, and ferritin variability were linearly linked to cognitive decline, regardless of their mean values. Furthermore, candidates in the highest quartile of variability score had a significantly worse cognitive decline rate in memory and verbal fluency than those in the lowest quartile. Higher variability in cardiometabolic and inflammatory parameters was significantly linked to cognitive decline. Stabilizing these parameters could be a goal for preserving cognitive functioning.