Llobet D, Vallvé C, Tirado I, et al. - A total of 324 individuals were assessed in the Riesgo de Enfermedad TROmboembólica VEnosa Study to determine whether levels of serotonin, serotonin transporter (SERT) and/or vesicle-associated membrane protein 8 (VAMP8) and these polymorphisms are correlated with the risk of venous thrombosis. The investigators observed statistically notable high levels of VAMP8 and SERT in patients but not in controls. Serotonin levels were lower in patients vs controls. Only women presented a statistically significant variation: the OR for VAMP8 was 3.25 when individuals were analyzed by sex. The adjusted OR did not vary. The OR for SERT was 2.76, and the adjusted OR was sustained as well. The adjusted OR was non-significant for serotonin, with an OR of 2.62. On the contrary, males did not exhibit significant variations. For both polymorphisms, no statistically variations between patients and controls were identified. Overall, in a female Spanish population, VAMP8 and SERT levels were related to venous thrombosis.