Yao X, Meng Y, Guo R, et al. - In the present study, the researchers sought to examine the value of ultrasound and immunohistochemistry in anticipating the presence of central lymph node metastasis (CLNM) and the prognosis of papillary thyroid carcinoma (PTC). The ultrasound and immunohistochemistry characteristics of 303 patients with first-ever PTC and who had surgery between 01/2014 to 12/2016 were analyzed, as well as the prognosis of the patients. In order to determine the risk factors of CLNM and recurrence, univariable and multivariable analyses were performed. Of the 303 patients, 125 (41.3%) were pathologically confirmed with CLNM. Multivariable analysis demonstrated that independent risk factors for CLNM were multifocality, taller-than-wide shape, grade III–IV blood flow, capsular invasion, Ki-67 > 10%, p53 ≥ 5%, T2 or T3 stages. Prophylactic CLNM dissection might be indicated for PTC with rich blood flow, taller-than-wide shape, multifocality, capsular invasion, p53 ≥ 5%, Ki-67 > 10%, T2 or T3 stages. The clinical outcome was affected by age ≥ 55 years, maximum tumor diameter > 20 mm, multifocality, capsular invasion, high Ki-67, p53 ≥ 5%, T3 and N1a stages.