Ajufo E, Ayers CR, Vigen R, et al. - This study was sought to analyze the relationship between coronary artery calcium (CAC), bleeding, and atherosclerotic cardiovascular disease (ASCVD) and investigate the net estimated effect of aspirin at different CAC thresholds. Researchers examined data between February 1, 2020, and July 15, 2020. The analysis enrolled a sum of 2,191 participants (mean [SD], age 44 [9.1] years, 1,247 women [57%], and 1,039 black individuals [47%]) had 116 major bleeding and 123 ASCVD events over a median follow-up of 12.2 years. It has been reported that higher CAC is correlated with both ASCVD and bleeding events, with a stronger relationship with ASCVD. According to the results, a high CAC score distinguishes individuals estimated to derive a net advantage from primary prevention aspirin therapy from those who would not, but only in the setting of lower bleeding risk and calculated ASCVD risk that is not low.