Schurink NW, Min LA, Berbee M, et al. - This study was conducted to investigate the value of multiparametric MRI combined with FDG-PET/CT to identify well-responding rectal cancer individuals before the start of neoadjuvant chemoradiation. Researchers retrospectively examined a total of 61 locally advanced rectal cancer individuals who underwent a baseline FDG-PET/CT and MRI (T2W + DWI) and received long-course neoadjuvant chemoradiotherapy. It was noted that the optimal multivariable prediction model consisted of a combination of baseline + quantitative imaging parameters and carried mrT-stage, T2W-signal entropy and T2W volume as the selected predictors. Before the start of treatment, a multivariable model including mrT-stage and quantitative parameters from baseline MRI can aid in distinguishing well-responding individuals.