Shuvy M, et al. - Researchers investigated if the addition of the CHA₂DS₂-VASc score to the Global Registry of Acute Coronary Events (GRACE) score might allow for an improved risk stratification in patients with acute coronary syndrome (ACS). Overall 6,854 ACS patients were included in this analysis. Participants were classified into high (> 140), intermediate (110 < GRACE score ≤ 140) and low (< 110) GRACE score. Based on the CHA₂DS₂-VASc score, each group was further subclassified into three groups: 0-1, 2-3, and ≥ 4. Comparisons for management and outcomes were performed. Improved risk stratification of patients with low and intermediate risk was offered by adding CHA₂DS₂-VASc score to the GRACE risk score in ACS patients. A 57% increase in 1-year mortality rates was observed in relation to each 1-point increase in the CHA₂DS₂-VASc score among patients with a GRACE score < 140.