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Validation of water-fat MRI and proton MRS in assessment of hepatic fat and the heterogeneous distribution of hepatic fat and iron in subjects with non-alcoholic fatty liver disease

European Journal of Radiology Aug 16, 2018

Hui SCN, et al. - Researchers performed comparison and validation of in-house hepatic fat measurements using water-fat MRI and MRS as well as quantified hepatic fat-fraction and T2* values in left and right liver lobes using water-fat MRI by analyzing data of 54 non-alcoholic adults and 46 non-alcoholic teenagers. Using MRS and water-fat MRI, hepatic fat measurements were statistically equivalent. They found that hepatic fat was stored preferentially in the right live lobe probably due to the streamline of blood flow to the right liver in patients with non-alcoholic fatty liver disease (NAFLD) irrespective of their age. It was noted that T2* value was significantly higher in the right liver lobe in adults but not in the teenagers despite their hepatic fat contents probably due to the longer time span of hepatic iron accumulation.
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