Hilty MP et al. – This study validated transpulmonary thermodilution in hemodynamically stable patients (N = 29) with heart disease by assessing the validity of cardiac output, global end–diastolic volume index (GEDVI), global ejection fraction (GEF), cardiac function index (CFI), and extravascular lung water index (EVLWI). The results of the study demonstrated that measurement of cardiac output by transpulmonary thermodilution was unaffected by differences in ventricular size and outflow obstruction. However, markedly enlarged left ventricular end–diastolic volumes were not identified by GEDVI, and neither GEF nor CFI indicated increases in heart chamber volumes and marked impairment of left ventricular function in patients with dilated cardiomyopathy. The authors opined that EVLWI may be a sensitive marker of subclinical pulmonary edema, especially in patients with increased left–ventricular–filling pressure irrespective of differences in left ventricular function.