Silverberg JI, et al. - In this cross-sectional, population-based study, researchers determined the construct validity, internal consistency, cross-cultural validity and floor or ceiling effects of multiple atopic dermatitis (AD) severity assessments. The study sample consisted of 2893 adults, including 602 adults meeting a modified set of U.K. diagnostic criteria for AD. The severity of AD was evaluated using self-reported global AD severity, Patient-Oriented Eczema Measure (POEM), Patient-Oriented Scoring Atopic Dermatitis (PO-SCORAD) and its objective and subjective components, and numerical rating scale (NRS)-itch. According to findings, PO-SCORAD, PO-SCORAD objective and subjective subscores, NRS-itch and POEM seem to be valid for clinical practice assessment of AD severity. All scores displayed potentially weak cross-cultural validity as shown by uniform and nonuniform differential item functioning by age, sex and/or race/ethnicity for multiple items. POEM had floor effects, but not for other evaluations.