Iyer PG, Taylor WR, Slettedahl SW, et al. - A five methylated DNA marker (MDM) panel was identified previously for nonendoscopic Barrett’s esophagus (BE) detection, so researchers recalibrated the performance of the five MDM marker panel utilizing a simplified assay in a training cohort, as well as validated the panel in an independent test cohort. Further, they examined accuracy of an MDM panel with only three markers. From three medical centers they recruited 199 patients for the training set (110 BE cases, 89 controls), and there were 89 patients in the test set (60 BE cases and 29 controls). In BE cases and controls, the SOS device (EsophaCap, CapNostics, Concord, NC, USA) was five five MDM panel using a simplified assay. Outcomes suggest high accuracy of the five MDM panel for BE in training as well as test sets. There may be reduction of this panel to only three MDMs in the future, since multiple three MDM panels achieved similar accuracy.