Campbell AP, Ogokeh C, Lively JY, et al. - Researchers aimed at ascertaining the vaccine effectiveness (VE) against laboratory-confirmed influenza-associated hospitalizations and emergency department (ED) visits among children in the New Vaccine Surveillance Network. Molecular assays were used to test the children 6 months to 17 years with acute respiratory illness for influenza at 7 pediatric hospitals (ED patients < 5 years at 3 sites). Information concerning vaccination status was obtained from parental reports, state immunization information systems and/or provider records for 1,792 inpatients, and parental reports alone for 1,944 ED children. Findings revealed influenza vaccine effectiveness of 41% against influenza-related hospitalizations and 51% against influenza-related emergency department visits among children during the 2018–2019 US influenza season. Protection against both influenza A(H1N1)pdm09 and A(H3N2) was provided by the vaccination, despite circulation of antigenically drifted A(H3N2) viruses.