Pan KS, FitzGibbon EJ, Vitale S, et al. - This study was undertaken to investigate the ability of optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness measurements to distinguish optic neuropathy (ON) in fibrous dysplasia (FD) and to compare the performance of RNFL thickness to computed tomography measurements, and examine changes in RNFL thickness over time to assess disease progression. Researchers conducted a retrospective cohort study to evaluate individuals (n = 70) who had undergone neuro‐ophthalmologic examination, including OCT.  The receiver operator characteristic (ROC) curve analysis was applied to ascertain the diagnostic utility of RNFL thickness, and the accuracy was compared with computed tomography measurements. In this population, RNFL thickness of ≤ 71 μm accurately identified ON. Clinicians may distinguish between patients at risk for ON and intervene before irreversible damage by establishing the difference in the rate of RNFL thinning in patients with and without ON.