Ito T, et al. - Based on hepatic pathology and non-invasive fibrosis markers, researchers illuminated the prognosis of nonalcoholic fatty liver disease (NAFLD) patients, including non-liver-related diseases. Participants in the study were 246 Japanese patients with NAFLD diagnosed by liver biopsy. The present data indicated that the FIB-4 index was helpful to forecast overall survival, the incidence of HCC and liver cirrhosis (LC)-related complications, but not extra-hepatic malignancies. Findings suggested an association of severe liver fibrosis with the hepatocarcinogenesis and LC-related complications as well as with extra-hepatic malignancies.