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Uterine artery Doppler in singleton pregnancies conceived after in‐vitro fertilization or intracytoplasmic sperm injection with fresh vs frozen blastocyst transfer: Longitudinal cohort study

Ultrasound in Obstetrics & Gynecology Sep 17, 2020

Cavoretto PI, Farina A, Gaeta G, et al. - As gestational age and weight at birth are higher in pregnancies conceived by frozen blastocyst transfer (FBT) vs those derived by fresh blastocyst transfer, researchers here evaluated uterine artery pulsatility index (UtA‐PI) in pregnancies conceived by in‐vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) techniques using fresh vs cryopreserved blastocysts. In this prospective longitudinal study, they included a total of 367 IVF/ICSI cycles, comprising 164 with fresh blastocyst transfer and 203 with FBT, and collected and analyzed a total of 625 observations (median, 2.5 (range, 1–4)). Relative to the fresh‐blastocyst‐transfer group, the FBT group had on average 14% lower UtA‐PI. In pregnancies with SGA fetuses, 18% higher UtA‐PI was reported compared with pregnancies without; this was observed irrespective of the study group. They observed significantly lower birth‐weight centile and a higher rate of SGA in pregnancies that underwent fresh blastocyst transfer compared with those that underwent FBT. Per these findings, IVF/ICSI pregnancies conceived after FBT had lower UtA‐PI and lower proportion of SGA as compared with fresh blastocyst transfer. 

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