Changlai SP, et al. - In this investigation, researchers examined the impact of the acquisition of cine-averaged CT (CACT) incorporated with the patient's shallow breathing pattern on improving registration and lesion quantification. For this investigation, 30 cancer patients were enrolled in routine PET/CT followed by thoracic region CACT. Calculations were made for the misalignment between PET/helical CT (HCT) and PET/CACT. According to findings, all lesions in the PET/HCT images showed a misalignment greater than 5 mm, whereas in the PET/CACT images only 33% of lesions showed a misalignment greater than 5 mm. Data reported that the mean percentage difference between the maximum standardized uptake value (SUV^max) of CACT and that of HCT was 12%. Findings revealed that using the CACT technique and the shallow breathing pattern effectively lessens lesion misregistration and retrieves the underestimated SUV^max. The CACT method can be used for better management of cancer in the clinical practice of thoracic PET/CT.