Muscari A, Barone P, Faccioli L, et al. - Given their previous work comparing patients who were first diagnosed with atrial fibrillation (AF) with patients with large or small artery disease and obtaining the MrWALLETS 8-item scoring system for assessing the probability of undetected AF in patients with ischemic stroke, researchers here utilized cryptogenic strokes (CS) as the control group, as AF is normally sought among CS patients. One hundred ninety-one ischemic stroke patients (72.5 ± 12.6 years) were analyzed; 68 with first diagnosed AF and 123 with CS. The patients had undergone 2 brain CT scans, echocardiography, carotid/vertebral ultrasound, continuous electrocardiogram monitoring and anamnestic/laboratory search for cardiovascular risk factors. The “ACTEL” score, a simplified and improved version of the MrWALLETS score, comprised the following 5 variables that were identified to be independently linked with AF in logistic regression: age ≥ 75 years; hypercholesterolemia; tricuspid regurgitation ≥ mild-to-moderate; left ventricular end-diastolic volume < 65 mL; left atrium ≥ 4 cm. The ACTEL score was recognized as valuable for the classification of patients with first diagnosed AF, in the context of CSs, with a high positive predictive value.