Laufer-Perl M, et al. - Given that global longitudinal strain (GLS) is considered the best parameter for early detection of subclinical LV dysfunction according to the American and European Society of Echocardiography, researchers assessed the frequency of GLS reduction in patients with active cancer and its relationship to other echocardiographic parameters. Findings revealed GLS reduction was often detected among active cancer patients. In addition, GLS reduction preceded left ventricular ejection fraction reduction, and could not be anticipated by other echocardiographic parameters in these subjects. As per the observations, cardiotoxicity from cancer therapy could be diagnosed early by using GLS routinely during therapy.