Kim A, Im DH, Kim K, et al. - Since it is not always easy to look for mitotic figures and count them correctly on hematoxylin and eosin-stained (H&E) slides, therefore, through a study, the researchers intended to assess the benefits of anti-phosphohistone H3 immunoreactivity in determining the mitotic rate in gastrointestinal stromal tumors. Among phopho-histone H3 (PHH3)-MI and mitotic count on H&E sections (H&E-MI), a strong association was discovered. Recurrence-free survival was related to the risk category by NIH consensus criteria, mucosal invasion, H&E-MI, Ki-67 expression, and PHH3-MI. However, none of the formerly mentioned factors was an independent prognostic factor. Therefore, PHH3 staining was primarily discovered to sustain grading by promoting mitotic counting and it might have a prognostic value in the gastrointestinal stromal tumors.