Khalil S, et al. - In this case series of 15 patients, researchers evaluated change in disease severity score, in the treatment of autosomal recessive congenital ichthyosis (ARCI) after a 3-month therapeutic regimen consisting of a glycolic acid (10% to 20%) cream and a combination cream of lovastatin (2%) with cholesterol (2%). Between May 2017 and January 2018, this investigation was conducted at the American University of Beirut, a referral center in the Middle East region for genodermatoses. They observed that the average percentage reduction in the disease severity score was 33.7% at 2 months and 57.5% at 3 months. Irritation and burning were the main adverse effects, which were generally mild. A benefit was found from this treatment regimen in the treatment of ARCI. The study findings suggested that this therapeutic regimen might be used in difficult-to-treat ARCI as well as other dermatoses involving a defective skin barrier.