Glober N, et al. - Researchers sought to investigate the test characteristics of the high-sensitivity d-dimer for the diagnosis of pulmonary embolism (PE) at their institution. They, in addition, evaluated the use of the d-dimer and factors associated with a falsely elevated d-dimer. They recognized that many patients with negative d-dimer and Pulmonary Embolism Rule-Out Criteria (PERC) still received imaging. In this work, many risk factors (such as age, history of PE, recent surgery, shortness of breath, tachycardia, and hypoxia) elevated the d-dimer, regardless of the presence of PE. Data thereby supported the use of age adjustment, and perhaps adjustment for other factors seen in patients evaluated for PE.