Platts-Mills JA, et al. - Using quantitative diagnostic methods, researchers intended to reassess and refine estimates of diarrhoea aetiology from the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study, which was a multisite study of children aged 0–2 years done at eight locations. Findings showed estimates of pathogen-specific burdens of childhood diarrhoea in the community setting improved as a result of using quantitative molecular diagnostics. Predominance of viral cause, including a substantial burden of sapovirus was noted. A high incidence in the second year of life and the highest overall burden was noted for Shigella. The management of diarrhoea in these low-resource settings could be improved by considering these findings.