Kouwenhoven TA, et al. - An appraisal was performed of the utility of oral antidepressants in chronic pruritus. Oral antidepressants were to be recommended in patients with chronic pruritus which was unresponsive to topical treatment and oral antihistamines, especially in the case of patients with uremic pruritus, cholestatic pruritus, or paraneoplastic pruritus.